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The Home Office has published guidance on the Operation of the Animals (Scientific Procedures) Act 1986. The guidance includes information on the implementation of the 3Rs and is available at https://www.gov.uk/guidance/research-and-testing-using-animals#animals-in-science-regulation-unit-asru-guidance.
The Home Office regulator for the use of animals in science has recently signed a Memorandum of Understanding with the NC3Rs. The Memorandum of Understanding is published and available at:https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/734630/establishment-licence-holder-newsletter-august-2018.pdf