Decisions are based on the national CDF clinical prioritisation tool in conjunction with an assessment of median drug cost per patient. This evaluation is completed for each drug/indication under consideration and will result in an overall score based on a number of factors, including:
evidence of clinical benefit; survival and quality of life benefit; toxicity/safety; unmet need; and median drug cost per patient.
Unmet need is defined in the tool as:
“Degree of clinical unmet need, i.e. either the first demonstration of efficacy of a systemic therapy for the disease concerned or a step change for the clinical setting concerned.
No alternative treatment 3
Alternative Active standard treatment exists 0”
The Standard Operating Procedures are available on NHS England’s website at: