What actions are you taking in response to the draft study “COVID-19 vaccination and menstrual cycle changes: A United Kingdom (UK retrospective case-control study)”?

The MHRA monitors and rigorously evaluates reports of suspected vaccine side effects, and reviews and assesses other sources of safety information. Its most recent evaluation of reports of suspected side effects of period problems and unexpected vaginal bleeding does not suggest an increased risk of either menstrual disorders or unexpected vaginal bleeding following vaccination. The advice remains that the benefits of vaccination outweigh the risks for most people, and it is vitally important that people come forward for their first, second and booster vaccine doses when invited.

Women who experience changes to their periods that are unusual for them, that persist over time, or new vaginal bleeding after the menopause following COVID-19 vaccination, should contact their doctor. Also, as with any suspected side effects from COVID-19 vaccines, women are encouraged to report these via the MHRA’s Yellow Card scheme. The MHRA is keeping this issue under review and every report received contributes to improving the safety of medicines.