On Monday, at an event for cystic fibrosis sufferers organised by my hon. Friend Ian Austin, I heard something that I never want to hear again: a young woman in her 30s actively researching funeral plans because she has cystic fibrosis and knows there is no cure. My question is about the conversation between the National Institute for Health and Care Excellence, NHS England and Vertex, which has been at an impasse for almost three years now, about access to Orkambi for patients who need it. Pharmaceutical companies are of course entitled to make profit, and research and development is expensive and lengthy, but now that we have reached the point at which the Health and Social Care Committee is having to ask for transparency on the finances to try to break the impasse, we know we have to do something differently. Looking at the huge global forward profits for Vertex, will the Prime Minister personally work with the Health Secretary to break this impasse and get Orkambi to those patients who are desperate to relieve their cystic fibrosis symptoms?